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Research Article Open Access
Rapid and accurate high performance liquid chromatography method is described for simultaneous determination of paracetamol, thiocolchicoside and aceclofenac from the combination dosage form. The separation of three drugs was achieved on an Inertsil ODS (150 x 4.6 mm i.d.) with 5 μ particle size. The mobile phase consisted of buffer of pH 6.5 and acetonitrile in gradient elution system. The detection was carried out at wavelength 300 nm. The Inertsil ODS column showed the most favorable chromatographic parameters for analysis. The method was validated for system suitability, linearity, accuracy, precision, robustness and stability of sample solution. The linear ranges for paracetamol, thiocolchicoside and aceclofenac were 1250-3750 μg/ ml, 20-60 μg/ ml and 250-750 μg/ ml respectively. The method has been successfully used to assay of combined dosage form i.e. tablets containing 500 mg paracetamol, 8 mg of thiocolchicoside and 100 mg aceclofenac with good recoveries.
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Author(s): Rajan V Rele
Paracetamol, Thiocolchicoside, Aceclofenac, HPLC