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Artemisinin and its semisynthetic daughters having 1, 2, 4-trioxane ring system has become the drugs of choice in the treatment of malaria chemotherapy. The incorporation of substituents into the central peroxide ring as well as further ring annulation are efficient approaches for the preparation of other active derivatives and has attracted much attention worldwide for tackling the forthcoming problem of multi-drug resistant malaria. The present review addresses the most significant contemporary status of synthesis for 1, 2, 4-trioxane scaffolds as well as their hybrids as reported in the literature up to middle of 2012
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Author(s): Subhendu Chakroborty Chittaranjan Bhanja Satyaban Jena
Antimalarial, Artemisinin, Peroxide, Plasmodium, 1, 2, 4-Trioxanes.