alexa Abstract | Ameliorative action of aqueous extract of Acalypha indica against puffer fish Lagocephalus lunaris induced toxicity

International Journal of Drug Development and Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

Acalypha indica has been used in poisoning cases and are known to possess significant antioxidant activities. The objective of this study is to evaluate the protective effects of an aqueous extract (5 g/l) of A. indica (leaves and stems), on biochemical disorder, oxidative stress and histopathological changes induced by muscle extract of puffer fish Lagocephalus lunaris in swiss albino mice. Mice injected with L. lunaris muscle extract (1 ml/100g body weight) for 10 days showed (1) a reduced appetite and diarrhea resulting in a lower growth rate than controls, (2) an increase in serum Alanine aminotransferase, Aspartate aminotransferase, Alkaline phosphatase and Total & Direct bilirubin levels suggesting liver functional disorders, (3) an increase of serum creatinine and uric acid concentrations highlighting renal insufficiency and (4) increase in the level of serum triglycerides, total cholesterol, glucose and low density lipoproteins indicate the interference in the metabolism or biosynthesis of lipids (5) an oxidative stress as evidenced by the raise of TBARS and the inhibition of antioxidant enzymes (Superoxide dismutase, Catalase and Glutathione peroxidase) activities in liver, kidney and heart tissues (6) histopathological changes in liver, kidney and heart tissues. Absorption of A. indica aqueous extract as a drink, for 10 days demonstrated ameliorative action and prevented the disorders induced by L. lunaris muscle extract.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Niharika Mandal and Samanta Sekhar Khora

Keywords

Lagocephalus lunaris, toxicity assessment, biochemical disorders, oxidative stress and histopathology

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords