alexa Abstract | Anti-Adhesion Activity of Lactic Acid Bacteria Supernatant against Human Pathogenic Candida Species Biofilm

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Background: Candida spp. have the ability to form biofilms. This study observed the anti-adhesion activity of lactic acid bacteria (LAB) isolated from honey against five pathogenic Candida spp. biofilm. Four from twenty five LAB isolates showed anti-adhesion activity and were identified as Lactobacillus plantarum2 HS isolated from Al-Sedar honey, Lactobacillus curvatus HH isolated from Al-Hanon honey, Pediococcus acidilactici HC isolated from Tualang honey and P. pentosaceus HM isolated from Al-Maray honey by the 16S rDNA sequence.

Methods: The cell free supernatant (CFS) of these LAB isolates inhibited the adhesion of five Candida spp. biofilm in pre-coating and co-incubation experiments.

Results: In pre-coating method, L. curvatus HH significantly (P< 0.05) reduced the biofilm formation of Candida glabrata ATCC2001 by 79.4%, and C. albicans ATCC14053 by 61.1%. However, in co-incubation experiment, the supernatant produced by L. curvatus HH significantly (P< 0.05) reduced the biofilm formation of C. albicans, C. krusei and C. glabrata by 75.5%, 70% and 58.4%, respectively. The supernatant of L. plantarum HS did not significantly (P> 0.05) reduced the biofilm formation of C. glabrata and C. krusei. The anti-adhesion activity of CFS was stable after heat treatment (60, 80, 100°C) for 30 min and after autoclaving at 121°C for 15 min. The anti-adhesion activity of CFS was observed at pH 3 but, it was decreased at pH 6 and the activity was lost at pH 7. The CFS of L. curvatus HH was more effective at pH 7 especially against biofilm formation of C. glabrata ATCC 2001 and C. albicans ATCC 14053 with percentages 65.9 % and 58.6 %, respectively.

Conclusion: The results indicates that supernatant produced by LAB can be used to decrease the biofilm formation by Candida spp.

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Author(s): Zaiton Hassan


Lactic acid bacteria (LAB), Anti-adhesion activity, Pathogenic Candida spp, Personal Health, Health Issues, Health Regulation

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