alexa Abstract | Antibacterial activity of coumarine derivatives synthesized from 4-hydroxychromen- 2-one and comparison with standard drug

Journal of Chemical and Pharmaceutical Research
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Abstract

In present paper, we report the organic syntheses of three compounds from 4-hydroxy-chromen-2-one and describe the results of antibacterial activity of purified compounds viz: 4-(2-Hydroxy –phenylamino)-chromen-2-one (1a), 2- Hydroxy-N-(2-hydroxy-phenyl)-N-(2-oxo-2H-chromen-4-yl)-benzamide (2a), N-[7-(3-Acetyl-thioureido)-2-oxo-2Hchromen- 4-yl]-2-hydroxy-N-(2-hydroxy-phenyl)-benzamide (3a), have been synthesized and characterized using melting points , IR spectra , 1H-NMR and 13C-NMR spectra. The antibacterial activity of synthesized compounds and streptomycin and cefalexine at concentrations of 2mg/ml, 3mg/ml and 5mg/ml, have been evaluated against three strains of bacterial culture; Staphylococcus aureus, E.coli and Bacillus cereus. The compounds show bacteriostatic and bactericidal activity.

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Author(s): Islam Krasniqi Aziz Behrami Skender Demaku and Ilir Shehu

Keywords

Coumarine derivatives, antibacterial activity, IR, 1H-NMR, 13C-NMR, Streptomycine, Antibacterial activity

 
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