alexa Abstract | Antibacterial and antifungal activities of 2-arylidene-4-(4-methylphenyl)but-3-en-4-olides and their pyrrolone derivatives

Indian Journal of Pharmaceutical Sciences
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Starting from 3-3-(4-methyl-benzoyl)propionic acid and using appropriate reagents, some new 2-arylidene-4-(4-methylphenyl)but-3-en-4-olides (IIIa-g) and their corresponding pyrrolone derivatives (IVa-d) have been synthesized. These compounds were evaluated for their antibacterial activity against Staphylococcus aureus and Escherichia coli as well as antifungal activity against Candida albicans . The compounds have considerable antifungal activity and moderate antibacterial activity.

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Author(s): A Husain SM Hasan S Lal MM Alam

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