alexa Abstract | Antibacterial and antifungal activities of some novel thiolactosides

Indian Journal of Pharmaceutical Sciences
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Abstract

A series of novel thiolactosides like S -hepta- O -acetyllactosyl-1-arylisothiocarbamides (1a-g) and hepta- O -acetyl lactosyl arydithiocarbamates (2a-g) were prepared by the interaction of hepta- O -acetyl lactosyl bromide with arylthiocarbamides and ammonium aryldithiocarbamates respectively. Similarly (hepta- O -acetyl lactosyl)-1,5-disubstituted-2-isothiobiurets (3a-g) 1,5-disubstituted-2,4-isodithiobiurets (4a-g) and-1,2,4-thiadiazolines (5a-g) were synthesized by the interaction of (1a-g) with phenyl isocyanate, phenyl isothiocyonate and S -chloro- N -phenyl isothiocarbamoyl chloride respectively. The compounds 3-Aryl-2,6-diphenylimino 4-S-hepta- O -acetyl lactosyl-2,3dihydro-1,3,5-thiadiazines hydrochlorides (6a-g) were prepared by the interaction of (4a-g) with phenyl isocyanodichloride. In the present investigation activities of these thiolactosides against pathogenic bacteria and fungi such as E. coli, S. aureus, P. vulgaris, Salmonella typhi, Candida guilliermondii and A. niger are discussed.

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Author(s): DV Mangte SP Deshmukh DD Bhokare Aarti R Deshpande

 
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