alexa Abstract | Antibacterial, cytotoxicity and antiviral activities of Asplenium nidus

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

This study described the chemical and biological activities of leaves and roots of Asplenium nidusfractions. Methanol extracts of leaves and roots were fractionated using hexane, chloroform and ethyl acetate and the phytochemical contents were determined. High alkaloid and terpenoids were detected. Cytotoxicity towards Vero cells determined by MTT assay revealed the concentration that reduces 50% of cell viability (CC50) ranged from 0.12 to 1.87 mg/mL which can be considered assafe. The antibacterial activities of fractions were evaluated against eleven types of bacterial pathogens with theminimum inhibition concentration (MIC) and minimum bactericidal concentration (MBC). From the MIC and MBC values leaves chloroform fraction showed bactericidal against several bacteria. The selectivity indices (SI=CC50/ MIC) for antibacterial activity of each fractions varied from 0.006 to 0.3 indicating that these fractions have a potential as antibacterial agent. Antiviral activity using Herpes simplex virus Type-1 (HSV-1) showed all of the fractions have antiviral activity with effective concentration (EC50) values between 0.01 to 0.125 mg/mL. The selectivity indices (SI = CC50/EC50) for antiviral of each tested fractions ranged from 0.96 to 29.92 indicating the usefulness of the extracts as potential antiviral agents.

To read the full article Peer-reviewed Article PDF image

Author(s): Mariya Mohd Tahir Yip Chee Wai Wan Ahmad Yaacob and Nazlina Ibrahim

Keywords

Asplenium nidus, phytochemicals, antibacterial, antivirus, cytotoxicity

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords