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Research Paper Open Access
A number of new N-arylamino-3-chloro-4-(4'-dimethylamino) phenyl-azetidin-2-ones have been synthesized and their structures have been established on the basis of consistent elemental, IR, spectral data. Antibacterial activity has been performed using agar diffusion technique involving paper disc method against E. coli (445). Pseudomonas diminuta (MTCC 1609) and Bacillus subtilis (MTCC 441). All the synthesised azetidine-2-one have shown significant antibacterial activity. It has been observed that N-(4'-nitro) phenylamino-3-chloro-4-(4'-dimethylamino) phenyl azetidin-2-one is found to be more potent against E. coli. Molecular refractive index (MR) correlates linearly to the drug activity with correlation coefficient of 0.99.
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Author(s): Pratibha Sharma Priti Indapurkar Anupam Mandloi