alexa Abstract | Anticonvulsant activity of schiff bases of 3-amino-6,8-dibromo-2-phenyl-quinazolin-4(3H)-ones

Indian Journal of Pharmaceutical Sciences
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Abstract

Schiff bases (9a-l) of 3-amino-6,8-dibromo-2-phenyl-quinazolin-4-(3H)-ones (8) with various substituted aldehydes were obtained by refluxing 1:1 molar equivalents of the reactants in dry ethanol for 6 h. The aminoquinazoline (8) was inturn obtained from 3,5-dibromoantharlinic acid via intermediate (7). All the synthesized compounds (9a-l) were evaluated for their anticonvulsant activity on albino mice by maximal electroshock method using phenytoin as a standard. The compound (9l) bearing a cinnamyl function displays a very high activity (82.74 %) at dose level of 100 mg/kg b.w.

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Author(s): P Paneersalvam T Raj MPS Ishar B Singh V Sharma BA Rather

Keywords

Anticonvulsant, maximal electroshock method, Schiff base, Quinazolin-4-(3H)-one, 3-aminoquinazolines

 
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