alexa Abstract | Antidiabetic activity of the ethanol extract of Capparis sepiaria L leaves

Indian Journal of Pharmaceutical Sciences
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Abstract

Capparis sepiaria L, a profusely branched hedge plant, is used in Indian traditional medicine. Capparis sepiaria leaves were extracted with ethanol and concentrated to dryness. The LD 50 value was determined as 894.43 mg/kg body weight by acute toxicity study. The ethanol extract was investigated for possible hypoglycemic effect produced by single oral administration at various dose levels 100, 200 and 300 mg/kg in the streptozotocin induced diabetic rats and compared against normal saline control and the standard glibenclamide. A maximum fall of plasma glucose level 9.40%; 13.57%; 15.25% and 18.80% was observed after 12 h of treatment when administered with ethanol extract of Capparis sepiaria at 100, 200 and 300 mg/kg, and glibenclamide 10 mg/kg dose, respectively. The findings from the study suggest that the Capparis sepiaria leaves may be prescribed as an adjunct to traditional formulation and drug treatment for controlling diabetes mellitus.

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Author(s): P Selvamani S Latha K Elayaraja P Suresh Babu JK Gupta TK Pal LK Ghosh DJ Sen

Keywords

Capparis sepiaria, streptazotocin (STZ), antidiabetic activity and Capparidaceae

 
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