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Fenugreek (Trigonella foenum-graecumL. Leguminosae) is widely used in Indian Ayurvedic medicine for the treatment of diabetes mellitus. Antihyperglycaemic effect of the two different doses (200 and 400 mg/kg) of the fenugreek extract was evaluated in this study. Blood glucose, liver profile, renal profile and total lipid levels were determined in alloxan induced diabetic rats after oral administration of a fenugreek extract. A comparable hypoglycemic effect was evidenced from the data obtained after 7 and 21 days of oral administration of the extract. The extract lowered the total cholesterol and serum triglycerides. Histopathological analysis of pancreas showed normal acini, and normal cellular in the islets of langerhans in the pancreas of normal control and Extensive damage to islets of langerhans and reduced dimensions of islets in alloxan induced diabetes. Restoration of islets of langerhans seen in diabetic rats treated with fenugreek extract. The results of this study clearly shows the hypoglycaemic activity of the extract
Alloxan, Fenugreek, Diabetes Mellitus.