alexa Abstract | Anti-diabetic Effects of Methanol Extract of the Seeds of Buchholzia coriacea and its Synergistic Effects with Metformin

Asian Journal of Biomedical and Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

Diabetes Mellitus (DM) has an estimated world prevalence of 285 million adults with high morbidity and mortality rates especially in the developing countries. The preparations of the seeds of Buchholzia coriacea commonly known as wonder kola is used for the management of DM in Nigerian ethnomedicine. In view of this, we studied the antidiabetic effects of the methanol extract of the seeds to scientifically ascertain the folkloric use. Alloxan induced diabetic rats were used in the study. Determination of the blood glucose concentration was done using the One Touch Ultra mini glucometer. Also acute toxicity test was performed using the Lorke’s method. Result showed an oral median lethality dose (LD50) greater than 5000 mg/kg, an indication of high safety profile. The extract at 100, 200, 400 mg/kg doses exhibited percentage blood glucose reduction (PBGR) of 37.73, 12.30 and 11.30 % respectively after 4 hours treatment. The combination of extract (100 mg/kg) and metformin (100 mg/kg) gave a PBGR at 4th and 7th day treatment of 73.4 and 72.2 % respectively. Therefore, the extract of the seeds of B. coriacea has potential hypoglycaemic effects and exhibited synergistic actions with metformin, a standard oral hypoglycaemic agent.

To read the full article Peer-reviewed Article PDF image

Author(s): Theophine Chinwuba Okoye Peter Achunike Akah Chinenye Laura Ilogu Adaobi Chioma Ezike Collins Azubike Onyeto

Keywords

Buchholzia coriacea, Alloxan, Diabetes Mellitus, metformin

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords