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Research Paper Open Access
A number of Mannich bases of Isatin were synthesised and screened for anti-HIV activity. The Schiffâ€™s base derived from 5-Methylisatin and trimethoprim was converted into Mannich bases. The N-dimethyl (Pan I) and morpholino (Pan M) were the most active compounds in the series and gave maximum protection against HIV-1 (III B) strain.
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Author(s): S N Pandeya D Sriram E De Clercq Christophe Pannecouque Myriam Witvrouw