alexa Abstract | Antiinflammatory activity of a polyherbal formulation

Indian Journal of Pharmaceutical Sciences
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Abstract

The antiinflammatory activity of the polyherbal formulation Entox® was investigated in rats for acute and sub acute models of inflammation using carrageenan-induced rat paw edema and cotton pellet granuloma methods respectively at a dose of 300 mg/kg and 600 mg/kg administered orally. The formulation in doses of 300 mg/kg and 600 mg/kg showed 51.61% and 54.84% inhibition of paw edema, respectively at the end of 3 h. The percent inhibition of granuloma by cotton pellet method was 27.92% and 53.17%, respectively. The formulation showed a significant antiinflammatory activity in both the experimental models and the activity was comparable to that of the standard drug, indomethacin.

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Author(s): SR Deorukhakar A Dethe RR Vohra R Ghosh J Chaudhary V Kadam

Keywords

Entox ® , carrageenan, cotton pellet granuloma, antiinflammatory, polyherbal, formulation

 
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