alexa Abstract | "Anti-inflammatory activity of flavone and its methoxy derivatives-a structure activity study".

Indian Journal of Pharmaceutical Sciences
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Research Paper Open Access

Abstract

Flavone, its various methoxy derivatives and flavanone were investigated for their anti-inflammatory activity in carrageenin- induced paw edema in mice (acute) and cotton pellet granuloma in rats (chronic). In the acute study flavone,3,6,7, and 2,-methoxy flavones exhibited a dose related anti-inflammatory activity. However, compounds like flavanone, 5-and4'-methoxy flavones failed to show any anti-inflammatory response. In the chronic model, almost all the compounds except 4' - methoxy flavone exerted dose related anti-inflammatory effect. Thus a definite structure activity relationship could be observed in the anti-inflammatory activity of these compounds.



Author(s): NS Muthiah S Viswanathan P Thirugnansambantham MK Reddy V Vijayasekaran

 
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