alexa Abstract | Antimicrobial Resistance Pattern among Community-Acquired Gram-Positive and Gram-Negative Bacterial Bloodstream Isolates in India

Annals of Clinical and Laboratory Research
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Aim: To perform a retrospective analysis to assess the antimicrobial resistance pattern of gram positive- and negative- organisms involved in causing bloodstream infections. Antimicrobial susceptibility was performed using broth microdilution methodologies and results were interpreted using Clinical and Laboratory Standards Institute guidelines.

Results: This study included 1825 gram-positive and 2986 gram-negative isolates. Twenty-nine percent (108/372) of the Staphylococcus aureus isolates were methicillin resistant with high rate of susceptibility for glycopeptides (>95%). Among the Enterococcus species, 12.1% (18/154) isolates were vancomycin resistant; also conferring resistance to linezolid (3.3%, 5/154). Most gram negative organisms recorded high level resistance to cephalosporins (>70%), fluoroquinolones (>50%) and β-lactum agents (>65%). Extended-spectrum β-lactamases (ESBLs) were reported among 52.8% (346/655) of Escherichia coli; and of these, 5.3% (18/346) isolates conferred carbapenem resistance. Similarly, reduced carbapenem susceptibility was reported against Acinetobacter spp. (62-83%; [Acinetobacter baumannii, ~85%]) and Pseudomonas spp. (62%; [Pseudomonas aeroginosa, <50%]).

Conclusion: Thus, glycopeptides and carbapenems retain high antimicrobial activity against most gram positive- and gram negative- pathogens.

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Author(s): Viral Vadwai Vidya Nerurkar Mamta Kumari Uma Ramesh Sunanda Dey and Bibhu Ranjan Das


Blood stream infections, Antimicrobial resistance, Bloodstream pathogens, Clinical Laboratory Research, Clinical and Diagnosis, Blood Disorders

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