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The prevalence of antibiotic resistance among extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae has increased markedly in recent years. This could be attributed to association of multi drug resistance in ESBL producing isolates. The present study was aimed to determine the antimicrobial resistance profile of ESBL producing Klebsiella pneumoniae isolates from various clinical samples. In this study,250 cases of Klebsiella pneumoniae within 9 months from patients referring to Razi Hospital Marand were collected and identified by biochemical tests. ESBL screening and confirmation along with antimicrobial resistance test was done according to the Clinical Laboratory Standards Institute (CLSI) guidelines. Of the 250 isolates, 150 (60%) were identified as having ESBL phenotype. Over 100% of ESBL isolates showed resistance to Ceftazidime and least resistance was found to Meropenem (3.3%). The prevalence of ESBL is increasing day by day in nearly every center of different countries and necessary steps to prevent the spread and emergence of resistance should be taken.
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Author(s): Abolfazl Jafari Sales Behboud jafari Najiyeh beygoli
Klebsiella pneumonia , Extended Spectrum Beta Lactamase, Antimicrobial resistance.