alexa Abstract | Antinociceptive activity of methanolic extract of leaves of Vitis vinifera

Der Pharmacia Sinica
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

Vitis vinifera (Vitaceae) is traditionally used to treat some painful conditions. Purpose of the present study was to evaluate antinociceptive activity of methanolic extract of leaves of Vitis vinifera (MELV) and also its possible mechanism of action. Antinociceptive activity of MELV was evaluated in writhing, hot plate, tail flick and formalin models in mice (n = 6). To elucidate the mechanism of action, animals were pre-treated with opioid antagonist, naloxone (5 mg/kg) and muscarinic antagonist, atropine (5mg/kg) and subjected to hot plate test. Oral administration of MELV exhibited significant (p<0.05) antinociceptive activity in a dose dependent manner in writhing, hot plate, tail flick, and formalin models. Pre-treatment with atropine did not cause any change in antinociceptive activity of MELV, while, pre-treatment with naloxone significantly (p < 0.05) diminished the MELV antinociceptive activity in hot plate test. The MELV exhibits opioid-mediated antinociceptive activity at the peripheral and central levels, which supported the traditional use of the Vitis vinifera in the treatment of some painful diseases.

To read the full article Peer-reviewed Article PDF image

Author(s): Bodka Sadaiah K T Sunil Kumar CH N Kavitha S Manohar Babu and V Prabhakar Reddy

Keywords

Pain, Mice, Vitis vinifera, Vitaceae, Mechanism of action

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords