alexa Abstract | Anti-oxidant and anti-inflammatory activity of synthesized 3-substituted schiff bases of quinazoline 2, 4-diones

Journal of Chemical and Pharmaceutical Research
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Abstract

3-Substituted Schiff bases of Quinazolne-2,4-diones which belongs to the N-containing heterocyclic compounds. The aim of the present study is to study pharmacological study of 3-Substituted Schiff bases of Quinazoline2,4-diones. In the current course of work the novel Schiff bases of Quinazolne-2,4-diones have been synthesized and evaluated for Anti-oxidant and In vitro anti-inflammatory study. 3-Substituted Schiff bases of Quinazoline 2,4-diones have been evaluated for Antioxidant and anti-inflammatory activity. Antioxidant activity was evaluated by Ferric reducing antioxidant power (FRAP), 1,1-DPPH(2,2-diphenyl-1-picrylhydrazyl) And anti-inflammatory activity by membrane stabilization method. The newly synthesized compound F and I showed highest anti-oxidant activity .This compound was further evaluated for in-vitro anti-inflammatory activity by membrane stabilization method. The result of the present study thus demonstrates the anti-inflammatory and anti-oxidant activity of newly synthesized 3-Substituted Schiff bases of Quinazolne-2, 4-diones.

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Author(s): Deepali Gangrade and Sayali Lad

Keywords

Schiff base, Quinazoline 2,4-diones, Antioxidant, Anti‐inflammatory, Ferric reducing antioxidant power (FRAP),1,1-DPPH, membrane stabilization method, Anti-oxidant

 
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