alexa Abstract | Antistress Potential of Simvastatins in Chronic Immobilization Stress

Asian Journal of Biomedical and Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)


Objective: A pharmacological study to explore Anti stress Potential of Simvastatins in stress produced models of mice.
Method and Material
Male Albino mice weighing between 22-30 g of weight were obtained from B.R.N.C.P. Mandsaur Animal House. The animals were stabilized for 1 week; they were maintained in standard condition at room temp; 60 ± 5% relative humidity and 12 h light dark cycle. They had free access to food and water. Animals were acclimatized to laboratory conditions before the experiment. All the experiments were carried out between 09:00 and 15:00 h. The experimental protocols were approved by Institutional Animal Ethics Committee of B. R. Nahata College of Pharmacy, Mandsaur, (M.P.).1
Chronic Immobilization Stress- The animals in all the groups except control (normal) were subjected to immobilization stress daily in a prone position for 150 min for 5 consecutive days using simple adhesive tape (chronic stress). Animals were released by removing the tape after moistening with acetone.2
Result: With the help of investigation of biochemical parameters of different groups of animals we found that simvavastatin significantly lowered the stress and stressor.
Conclusion: Simvastatin significantly suppressed the stress.

To read the full article Peer-reviewed Article PDF image

Author(s): Patley C Patley R Singh N


Stress, Simvasatin, Mirror chamber

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version