alexa Abstract | Antithrombotic Prophylaxis with Fondaparinux in Two Pregnant Women with Previous Cerebral Vein Thrombosis

Journal of Rare Disorders: Diagnosis & Therapy
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Case Report Open Access


Fondaparinux, a subcutaneous synthetic pentasaccharide that selectively inhibit factor Xa, seems to be a safe and efficacious alternative to low molecular weight heparin in prevention and treatment of venous thromboembolism in pregnant women who had developed severe adverse reactions to heparin. Two women with previous cerebral vein thrombosis received antithrombotic prophylaxis during pregnancy with fondaparinux 2.5 mg od because of previous hypersensitivity to low molecular weigh heparin. No thrombosis recurrence, maternal or fetal bleeding were observed, but both newborns were small for gestational age. Antithrombotic prophylaxis with fondaparinux was effective and safe in two pregnant women with previous cerebral vein thrombosis, but its potential side effects on fetal growth should be further elucidated. Low molecular weight heparin (LMWH) is the drug of choice for the treatment and prevention of venous thromboembolism (VTE) in pregnancy [1]. Adverse reactions to LMWH, i.e., local skin reactions, systemic rash and heparin induced thrombocytopenia (HIT) may occur and impose LMWH discontinuation and its avoidance thereafter [1]. Fondaparinux, a subcutaneous synthetic pentasaccharide that selectively inhibit factor Xa, seems to be a valid alternative to LMWH for both treatment and prophylaxis of VTE also during pregnancy [1], but data are limited to case reports or case series [2-8]. We report on the successful use of antithrombotic prophylaxis with fondaparinux in two pregnant women with previous cerebral vein thrombosis who had developed HIT (case 1) and severe skin reaction (case 2) during LMWH treatment. 15th,

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Serena M Passamonti Francesca Gianniello and Ida Martinelli


Rare blood disorders, Orphan Diseases

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us