alexa Abstract | Anti-typhoid and hepatic response in Salmonella typhi infected rats treated with ethanol leaf extract of Tithonia diversifolia

Asian Journal of Plant Science & Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

Ethanol leaf extract of Tithonia diversifolia was investigated for its anti-typhoid and hepato-curative activity in Salmonella typhi infected rats. The phytochemical composition and acute toxicity dose (LD50) of the plant extract were also evaluated. Total number of twenty-four wistar rats without sex discxrimination, distributed into six groups (n = 4) were used for this study. Group II-VI animals were infected with pure isolate of Salmonella typhi and administered 0.2 ml of distilled water, 0.5 mg/kg body weight of Amoxil, 0.5 mg/kg b.w of chloramphenicol, 200 and 400 mg/kg b.w of the extract respectively, Group I animals serve as normal control. The result of the quantitative phytochemical screening reveals high concentration of terpenoids, alkaloids, flavonoids, steroids and tannins. The acute toxicity study reveal the lethal dose (LD50) of the extract to be equal to or greated than 5000 mg/kg body weight. The plant extract was effective against Salmonella typhi on rats infected with the bacteria as shown by the widal test. The result of the biochemical studies showed significant (p<0.05) increase in plasma AST, ALT, ALP and bilirubin level of the animals infected with Salmonella typhi and treated with 0.5 mg/kg b. w of Amoxil and Chloramphenicol, 200 and 400 mg/kg body weight of the leaf extract compared with the infected rats administered 0.2 ml of distilled water. The histological study revealed changes in the hepatic histo-architecture consistent with inflammatory changes varied in severity ranging from mild to moderate and severe with or without hepatocellular coagulative necrosis. The curative property of Tithonia diversifolia extract in Salmonella typhi infected animals suggested that, Tithonia diversifolia could be used in the management of typhoid fever and hepatic damage or injury resulting from typhoid infection. The active compounds in the extract might have antioxidative activity, protecting against oxidative damage.



Author(s): Damilola Alex Omoboyowa Garba Jeremiah Danladi Wilson I Egwurochi and Ume Ukwa Agwu

Keywords

Anti-typhoid, Phytochemical, LD50, Histological, Salmonella typhi, Plant Biochemistry, Plant Microbiology

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords