alexa Abstract | Antiulcer activity of Wrightia tinctoria (Roxb.) R.Br

Der Pharmacia Sinica
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Research Article Open Access

Abstract

The purpose of the present study was aimed at evaluating the antiulcer activity on leaves of Wrightia tinctoria (Roxb) R.Br (Family Apocynaceae) on albino rat. The antiulcer activity of the Wrightia tinctoria methanolic extract (TM) and Wrightia tinctoria 70% ethanolic extract (T70E) were compared with carboxy methyl cellulose (CMC), pylorus control, Aspirin and standard famotidine which was evaluated by employing aspirin plus pylorus ligation induced ulcer model. The Biochemical parameters like volume of gastric juice secretion, pH, free acidity, total acidity, ulcer index and percentage inhibition were studied at the concentration of 200 mg/kg body weight. The plant methanolic extract showed significant gastro protective activity of 65.89% when compared with the standard drug famotidine (20 mg/ kg) which showed 75.34%. The result suggested that the methanolic extract of Wrightia tinctoria leaves possesses anti-ulcer effect. The observed effect may be due to the presence of bioactive constituents.

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Author(s): MadhuC Divakar and Lakshmi Devi S

Keywords

Biochemical parameters, Ulcer index, Percentage inhibition, Aspirin plus Pylorus ligation, Famotidine

 
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