alexa Abstract | Artritis Reumatoide: Prevalencia, inmunopatogenia y antígenos relevantes para su diagnóstico

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Abstract

La artritis reumatoide es una enfermedad cuyo origen implica factores genéticos, ambientales, étnicos, geográficos y nutricionales. Se caracteriza por afección principalmente de las membranas sinoviales de las articulaciones diartrodiales. La prevalencia en algunas zonas de la república mexicana es muy elevada, incluso superior a otras zonas del país y del mundo. En la artritis reumatoide, los linfocitos Th17 se asocian al efecto proinflamatorio producido por la secreción de IL-17, además de estimular la diferenciación de los osteoclastos y promover la destrucción de cartílago y hueso junto con IL-1 e IL-6. En la actualidad por su alta especificidad, se usan los péptidos cíclicos citrulinados como herramienta de diagnostico de acuerdo a los nuevos criterios de clasificación establecidos por el Colegio Americano de Reumatología y la Liga Europea Contra el Reumatismo.

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Author(s): Eber OlivaGutirrez Mayra Paulina MartnezGodoyMartn ZapataZiga Sergio Hugo SnchezRodrguez

 
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