alexa Abstract | Assessment of melatonin and cortisol levels in sickle cell anemia children: a single center based study.

Biomedical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)


Objective: To correlate serum levels of melatonin and cortisol in sickle cell anemia (SCA) with age, age at diagnosis, sex, anthropometry, vaso-occlusive crisis (VOC) and current treatment.

Methods: Twenty nine patients and 29 controls were recruited into this study. Melatonin and Cortisol assays were performed using commercially available ELISA kit. Statistical analysis was done to assess the difference in mean melatonin and cortisol levels and correlate these with age, age at diagnosis, sex, anthropometry, Vaso-Occlusive Crisis (VOC), current treatment.

Results: There was a significantly lower melatonin serum levels in SCA patients compared to controls (p<0.001). Melatonin was negatively correlated with age, vaso-occlusive crisis and cortisol (r=-0.02, p=0.9), (r=-0.13, p=0.5), (r=-0.28, p=0.15) respectively. However, melatonin levels were not correlated with other parameters including weight and height. There was slightly small difference in the mean levels of cortisol in patients compared to controls, but this difference was not statistically significant. Similarly, no correlation with age, weight, or height was noted. There was no difference in mean serum levels of melatonin and cortisol between males and females of SCA patients also, between that receiving HU when compared with that not receiving HU.

Conclusion: In the present work, we observed a significant decrease in melatonin level in SCA patients compared to controls. This highlights melatonin importance as a therapeutically agent for developing antioxidant defence. The use of melatonin will certainly help in decreasing oxidative damage and will ultimately results in detracting symptoms associated with SCA.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Marwa M ElSonbaty Mohammed AA Al Zolaly Shereen A El Tarhouny Zakaria MH Al Hawsawi


Sickle cell anemia, Melatonin, Cortisol, Children, #

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version