alexa Abstract | Assessment of the suspending properties of naturally occurring Entandrophragma angolense gum in oral sulphamethoxazole suspension

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

The need to reduce costs of pharmaceutical suspensions and consequently enhance affordability has culminated in the search for a pool of naturally occurring excipients that are biodegradable, economically feasible and can also compete with established agents. A study was conducted on the suitability of Entandophragma angolense gum as a suspending agent in oral pharmaceutical suspensions in comparison with official gelatin BP and Acacia gum. The gum was characterized and used in formulating sulphamethoxazole suspensions containing different concentrations (1.0 - 4.0 % w/v) of the gum; comparison was made with similar formulations containing gelatin BP and Acacia gum. Rheological properties, particle size analysis, suspending properties at varying pH values and stability at different temperatures were the assessment criteria for comparing the suspending ability of the polymers. Entandrophragma angolense gum is devoid of alkaloids, but contains carbohydrates, reducing sugars and saponins, which are pointers to its emulsifying properties. At all concentrations employed, the suspending ability of the polymers was found to be in the order: Entandophragma angolense > Acacia gum > Gelatin. The gum, thus, has potential as a suspending agent that can be exploited for use in the pharmaceutical industry.



Author(s): Oladapo A Adetunji and Mosunmola O Odole

Keywords

Entandophragma angolense, Natural polymers, suspending agents, sulphamethoxazole, particle size., suspending properties

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords