alexa Abstract | Atypical Haemolytic Uraemic Syndrome Associated with Cabazitaxel in Advanced Prostate Cancer

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Abstract

Atypical haemolytic uraemic syndrome, (aHUS) is a rare but potentially lifethreatening condition with clinical manifestations of haemolytic anaemia, thrombocytopenia, and renal failure. We report the first case of aHUS secondary to cabazitaxel in the setting of metastatic castrate resistant prostate cancer. In July 2015, a 73 year old male presented with acute on chronic back pain, in the context of metastatic castrate-resistant prostate cancer with known pulmonary and skeletal metastases. He was day 3 into his first cycle of cabazitaxel. Within 24 hours of admission, he acutely deteriorated with progressive drowsiness and the development of an acute kidney injury. During this period, he developed acute thrombocytopenia, falling to 58 x 109/L and haemolytic anaemia. He had a coagulopathy, with an elevated INR 1.5, but with a normal APTT and fibrinogen levels. He was subsequently diagnosed with an atypical haemolytic uraemic syndrome. In light of his rapid decline and poor prognosis he was managed with conservative treatment. Over the next 24 hours, he developed progressive acute renal failure and ongoing haemolysis. There was further neurological deterioration which culminated in his passing away three days following his initial presentation. With the

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Author(s): Abhishek Tumma

Keywords

Cabazitaxel, Atypical Haemolytic Uraemic Syndrome (aHUS), Prostate cancer, Renal failure, Medical case reports,clinical case reports

 
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