alexa Abstract | Atypical Log D profile of rifampicin

Indian Journal of Pharmaceutical Sciences
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Research Paper Open Access

Abstract

The distribution coefficient (log D) values of rifampicin, an essential first-line antitubercular drug, at gastrointestinal pH conditions are not reported in literature. Hence determinations were made using n-octanol and buffers ranging between pH 1-7. Also, log D values were predicted using Prolog D. Both the determinations showed opposite behaviour. The atypical experimental log D profile of rifampicin could be attributed to its surface-active properties, which also explained the reported permeability behaviour of the drug in various gastrointestinal tract segments.

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Author(s): TT Mariappan Nishi Sharda Saranjit Singh

 
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