alexa Abstract | Bactericidal activity of methanol extracts of crabapple mangrove tree (Sonneratia caseolaris Linn.) against multi-drug resistant pathogens

Indian Journal of Pharmaceutical Sciences
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Research Paper Open Access

Abstract

The crabapple mangrove tree, Sonneratia caseolaris Linn. (Family: Sonneratiaceae), is one of the foreshore plants found in estuarine and tidal creek areas and mangrove forests. Bark and fruit extracts from this plant have previously been shown to have an antiâ??oxidative or cytotoxic effect, whereas flower extracts of this plant exhibited an antimicrobial activity against some bacteria. According to the traditional folklore, it is medicinally used as an astringent and antiseptic. Hence, this investigation was carried out on the extract of the leaves, pneumatophore and different parts of the flower or fruit (stamen, calyx, meat of fruit, persistent calyx of fruit and seeds) for antibacterial activity using the broth microdilution method. The antibacterial activity was evaluated against five antibiotic-sensitive species (three Gram-positive and two Gram-negative bacteria) and six drug-resistant species (Gram-positive i.e. Methicillinresistant Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium and Gram-negative i.e. Extended-spectrum beta-lactamase-Escherichia coli, multidrug-resistant–Pseudomonas aeruginosa and Acenetobacter baumannii). The methanol extracts from all tested parts of the crabapple mangrove tree exhibited antibacterial activity against both Gramâ??positive and Gramâ??negative bacteria, but was mainly a bactericidal against the Gramâ??negative bacteria, including the multidrugâ??resistant strains, when compared with only bacteriostatic on the Gramâ??positive bacteria. Using Soxhlet apparatus, the extracts obtained by sequential extraction with hexane, dichloromethane and ethyl acetate revealed no discernable antibacterial activity and only slightly, if at all, reduced the antibacterial activity of the subsequently obtained methanol extract. Therefore, the active antibacterial compounds of the crabapple mangrove tree should have a rather polar structure.

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Author(s): C Yompakdee S Thunyaharn T Phaechamud

Keywords

Antimicrobial activity, bactericidal, crabapple mangrove tree, drug resistant bacteria, Sonneratia caseolaris Linn

 
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