alexa Abstract | Biomarker Controversies and Diagnostic Difficulties in Alzheimer’s Disease

American Journal of Phytomedicine and Clinical Therapeutics
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Alzheimer’s disease (AD) can be difficult to diagnose particularly in the earlier stages of illness when the symptoms are mild. In April 2011, National Institute on Aging(NIA)-Alzheimer’s Association published a new criteria for diagnosing AD revised to that of the NINCDS-ADRDA Alzheimer's Criteria proposed in 1984 by the National Institute of Neurological & Communicative Disorders & Stroke and the Alzheimer's Disease & Related Disorders Association (now known as The Alzheimer's Association).As per 1984 criteria the diagnosis of AD is mostly based on Neuropsychological assesment for possible & probable AD, while it needs Autopsy for Definite AD.The new 2011 criteria includes certain phases of dementia & 5 biomarkers which helps in improving an earlier clinical diagnosis of AD i.e preclinical AD(presence of AD pathology in the absence of symptoms & signs of dementia). The Aβ deposition & elevated tau can be seen even in other neuropsychiatric disorders other than AD which created the diagnostic dilemma.

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Author(s): GMahesh and Tasneem Shazia


Neurofibrillary tangles, Neuritic plaques, Alzheimer’s Disease, Phytomedicine, Therapeutics

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