alexa Abstract | Biomarkers Analysis for Heterogeneous Immune Responses of Quiescent CD8+cells -A Clue for Personalized Immunotherapy

Biomarkers Journal
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)


We have discovered that CD8+cells actively display quiescent status in tumor environment with several pathways. Moreover, heterogeneous immune responses from different patients’ CD8+ cells have been confirmed by genomewide association study (GWAS). Therefore, heterogeneous immune responses of CD8+ cells from quiescent status to active status should be addressed by system biology for personalized immunotherapy.

Methods and Findings
After we measured mRNA expression level obtained from quiescent CD8+ cells of two liver cancer specimens, significant network with a discovery of their targeting compounds was uncovered in some subtle differences of mRNA gene expression detected in the heterogeneous responses of quiescent CD8 cells. Etoposide and taurine could inhibit REST (65%) and ERF (87%) in specimen-1; taurine inhibited both ERF and SKI and loratadine supressed SKI in specimen-2. Cytotoxic T lymphocyte (CTL) showed 61+5.6% by etoposide and 45+9% by taurine in specimen-1 and demonstrated 48+6% by taurine and 45+4% by loratadine in specimen-2.

Our results demonstrate that heterogeneous immune responses of CD8+ cells can be analysed by system biology for further personalized immunotherapy.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Biaoru Li George Liu Hongliang Hu JianqingDing Jie Zheng and Alex Tong


Personalized immunotherapy, Tumor-infiltrating lymphocytes (TILs), CD8+cells, Quantitative pathway, Network, Gene expression signature (GES), Biomarkers, Heterogeneous responses, Biochemical Markers, Molecular Biomarkers, Metabolomic Biomarkers.

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version