alexa Abstract | Biovailability of nitrofurantion from multiple w/o/w emulsions in man and the influence of the oil phase of the emulsion.

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Paper Open Access

Abstract

Eight healthy volunteers had an oral administration of a single 100mg dose of nitrofurantoin in tablet dosage form and water-in-oil-water(w/o/w)emulsions in a crossover fashion.The bioavailability of the drug was evaluated from the urinary excretion data of the unchanged drug. The extent of absorption and the periods of maintenance of the minimum effective urine concentration (MEUC) following absorption of the drug from the Soyabean oil-w/o/w emulsion were both significantly higher (p < 0.05) compared to the corresponding values for the archis oil-w/o/w emulsion. Also the same values for the tablet dosage form were lowest (p < 0.05). On the other hand, the rates of absorption of the drug from the different dosage forms showed no significant differences (p < 0.05). From the results of this study, it could be suggested that oral administration of the nitrofurantoin in the form of w/o/w emulsions could improve its bioavailability and therapeutic efficacy. Also, the nature of the oil phase of the emulsion is important in determining the extent of nitrofurantoin absorption.



Author(s): CO Onyeji JA oMotosho

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us