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Case Report Open Access
Introduction: It has already been reported in many types of malignant tumors that a solid metastasis can have a different histology and more aggressive state than the primary tumor.
Case presentation: We report the case of a 60-year-old smoker woman who presented with bone metastasis that histologically proved to be an adenocarcinoma. Bronchoscopy revealed a squamous cell lung cancer that – despite the different histology – was regarded as the primary tumor. Two weeks later a rapidly growing skin tumor developed that was also a squamous cell carcinoma, and was regarded as the distant metastasis of the endobronchial cancer.
Conclusions: In lung cancer it is important not to exclude the possibility of tumor dissemination even if the suspected primary tumor and the distant metastasis have different histologies.
Lung cancer, Different histology, Metastasis, Tumor heterogeneity, Bone Marrow Stem Cells,Autoimmune Skin Diseases,Lung Cancer