alexa Abstract | Cambios en la extracción celular de oxígeno en el enfisema pulmonar subclínico

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Abstract

El diagnóstico del enfisema pulmonar subclínico frecuentemente escapa a las pruebas funcionales respiratorias (pFP)y tomografía computarizada de alta resolución (TCAR). Proponemos que cambios en la extracción celular de oxígeno(ERO2) en el enfisema pulmonar subclínico anteceden a los cambios por TCAR o pFP. Se estudiaron con pFP, TCARy ERO2 cuarenta adultos entre 20 y 72 años de edad (media 41.6 ± 4 años), con o sin tabaquismo, con o sin síntomas.Se determinó sensibilidad, especificidad y valores predictivos positivos y negativos para cada prueba, comparándoseentre sí. La sensibilidad y especificidad para pFP fueron de 13 y 84%, para TCAR de 33 y 76% y para ERO2 de 85 y67% (p < 0.001). La diferencia del ERO2 entre pacientes asintomáticos y sintomáticos (30% contra 41%, p < 0.001) fuesignificativa. Se concluyó que el diagnóstico del enfisema pulmonar subclínico debe incluir el estudio de ERO2.

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Author(s): Miguel Jess Betancourt Snchez Blanca Mara Jaime Surez Clara Lilia Rodrguez Islas Nahima Delon Huerta

 
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