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Original Articles Open Access
Candesartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension. The main aim of the research work is to formulate and evaluate Candesartan niosomes using Span 60 as a non-ionic surfactant. Niosomes are prepared using the ether injection method and are characterized for size, shape, entrapment efficiency and in vitro drug release. SEM studies have been carried out which shown that the niosomes are spherical in shape with smooth surface. All the vesicles appeared in the size range of 130- 170 nm. Percent entrapment efficiency has been carried out by dialysis method and found that increase in Span60 concentration increases the entrapment. Among all formulations, formulation F6 has shown highest entrapment efficiency 76.6%. Diffusion studies were carried out to study the drug release pattern from all formulations and are revealed that an increase in the concentration of surfactant decreases the drug release from niosomes, in all formulations prepared using span60. Stability studies were performed and the niosomes stored under refrigerated condition, showed greater stability. Formulation F6 was selected as an optimized formulation because of its good entrapment efficiency and slow drug release.
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Author(s): P Ravi Prakash M S Jayasheela R Raghavenra Prasad P Chandini A Praveena K Sree Lakshmi and P Ramesh
Candesartan, niosomes, span60, ether injection method, entrapment., surafactant