alexa Abstract | Case Report: Immunohistochemical analysis of a case of urothelial carcinoma of the renal pelvis showing gland-like lumina

Biomedical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

A Japanese woman in her mid-seventies presented with a case of urothelial carcinoma (UC) of the renal pelvis showing a peculiar gland-like lumina (GLL) pattern and exhibiting no evident glandular structure or mucin production. She showed macroscopic hematuria and experienced left lumbar pain for 2 months. After detailed examination, renal pelvic tumor and bilateral cortical adenoma of the adrenal glands were diagnosed, followed by nephrectomy and adrenalectomy of the left kidney by using the retroperitoneal laparoscopic method. Histopathological examination of the pelvic tumor revealed a grade 2 UC with GLL, which exhibited a smooth transition from ordinary UC to GLL with respect to its morphology. No mucinophilic materials were detected in the GLL areas, which showed distinct trabecular, circular, or meshwork arrangement of tumor cells without a defined glandular structure. Immunohistochemical findings showed that both ordinary UC and peculiar GLL areas were similarly stained when cytokeratin antibodies such as AE1/AE3, CAM5.2, CK7, CK20, and p63, were used. No neuroendocrine differentiation was detected in the GLL. Additionally, the average MIB-1 labeling index of the UC was 5%, but was almost negligible in the GLL areas. Furthermore, the GLL possessed only weak proliferative activity. Thus, prognosis of such a UC with GLL is probably similar to that of an ordinary UC without the GLL. Because of its rarity and the presence of a peculiar histopathological pattern of tumor cells, the histogenesis of such a tumor should be further investigated in further accumulated cases. (to be the same character with the others, please)

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Yuji Ohtsuki Naoto Kuroda Tokuhiro Iseda Yuhei Okada Yuki Matsuka Masako Izumimoto Wakana Tanihata GangHong Lee Mutsuo Furihata

Keywords

Renal pelvis, Urothelial carcinoma, Gland-like lumina, Immunohistochemistry, MIB-1

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us