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Cefpodoxime proxetil, a third generation antibiotic used to treat upper and lower respiratory tract infections is bitter in taste thereby hampering the development of a palatable oral dosage form. In this study, Cefpodoxime proxetil was taste masked by microencapsulation technique (solvent evaporation method) with methacrylic acid copolymer (EcopolTM) in various ratios of drug and polymer. The taste masked microspheres were incorporated into dispersible tablets and dry syrup for reconstitution. Tablets were prepared by direct compression technique. Dry syrup was prepared using sweeteners, flavors and diluents. The formulations were evaluated for quality control parameters. Results indicated successful formulation of mouth dissolving tablets and dry syrup for reconstitution with optimum physicochemical properties.
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Author(s): Naikkhanvte NS Kapuriya N Rajarajeshwari N