alexa Abstract | Cellular uptake of chitosan nanospheres by HEP G2 cells phagocytosis

Journal of Chemical and Pharmaceutical Research
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Abstract

No reports have discussed this point before that. Chitosan nanospheres (CNPs) with an average size of 110 nm and positive potential of +27.8 mv have been prepared via chemical ion gelation method and characterized by spectroscopy and electron microscopy. Hep G2 cell line is a suitable host for Hepatitis C Virus (HCV) replication. Hep G2 was treated with a concentration of 100μg/mL (w/v) of CNPsto investigate their effect on Hep G2. Visible cell aggregations and granulations took place in the tissue culture flask after 48 hours. This may be mediated, in part; by Hep G2 phagocytosis, which has been recorded with electron microscopy 24 hours post treatment. Thus, CNPs might attain the critical aim of drug delivery in a persistent HCV culture

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Author(s): Yousry Mahmoud Gohar Samah Aly Loutfy Amira Zaky AbdelRahman Nabawi Zekri Ahmed Mahmoud Mayla and Moustafa Youssef ElNaggar

Keywords

Chitosan, Nanospheres, Hep G2, Phagocytosis, anti-HCV Drug Delivery, nanospheres

 
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