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Research Paper Open Access
Considering the high lipophilicity (log P=7.41) of centchroman playing a critical role in the mediation of its biological activities (both therapeutic and toxic), effects of the drug on blood lipid constituents were studied using goatâ€™s whole blood as the lipid source. The results reveal that the drug has significant affinity in binding with phospholipid which is further corroborated by changes in fatty acid composition. Lipid binding potential of the drug may have role in its therapeutic effect. Lipid peroxidation induction potential of centchroman has been quantitatively measured in the context of its toxicity. However, the drug does not cause significant extent of lipid peroxidation and this is in good agreement with its safety record.
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Author(s): A Saha A U De C Sengupta