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The present case was phenotypically male except that testes were not present in the scrotum. Hence in this case of “cryptorchidism”, the genetic study becomes imperative for thorough analysis. Chromosomal study revealed more than 13.3 % centromeric breaks per cell in metaphase. The high incidence (3.6%) of common fragile sites expression (7q11, 2q21, 3p14) were also noticed after addition of 5-azacytidine. These “genetic factors” might influence the weight of the testis or alter hormonal level which is essential for normal growth and descent of testis in mammals.
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Author(s): Ajit Kumar Saxena Divya Singh Gajendra Singh
5- Azacytidine, Crytorchidism, Fragile sites, Centromeric breakage