alexa Abstract | Central nervous system depressant activity of cinnamic acid derivatives

Indian Journal of Pharmaceutical Sciences
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Research Paper Open Access

Abstract

Fourteen cinnamic acid derivatives with substitution in the phenyl ring were tested for CNS depressant activity by prolongation of pentobarbitone induced sleep. Halogenated cinnamic acids showed significant activity. QSAR by regression analysis showed that hydrophobicity of the substituents is importent for activity. All the cinnamic acids studied are present in ionized form at physiological pH.



Author(s): M NA Rao PN Ramanan DR Kulkarni

 
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