alexa Abstract | Characteristics of pegylated niosomal letrozole

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

Letrozole is one of the hormonal anticancer drugs which can be employed to treat aromatase dependent breast cancer. Aromatase is an enzyme that catalyses biosynthesis of estrogen from testestrone (androgen).Letrozole was loaded onto pegylated niosomes through reverse phase evaporation technique. Letrozole pegylated niosomes was characterized by dynamic light scattering spectroscopy (195.2 nm pegylated niosome and 234.1 nm letrozole pegylated niosomes), scanning electron microscopy and its entrapment efficiency was calculated to be 66.6% . The drug released pattern (in vitro) from the pegylated niosomes was studied through zero order, first order, Higuchi and Hixson – Crowell kinetics models. It was found that the release pattern followed first order and Hixson- Crowell models. Finally, the IC50 values for pure letrozole and letrozole pegylated niosomes were found to be 0.051 μM and 0.0287 μM, this indicated that the toxicity of drug pegylated niosomes is more than the pure drug.

To read the full article Peer-reviewed Article PDF image

Author(s): Azizi S and Norouzian D

Keywords

Letrozole, pegylated niosome, drug delivery, release kinetics., niosomal letrozole

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords