alexa Abstract | Characterization and evaluation of spray dried co-processed excipients and their application in solid dosage forms

Indian Journal of Pharmaceutical Sciences
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Research Paper Open Access

Abstract

Major challenge for tablet manufacture comes from the powder characteristics of the materials to be compressed. This in turn poses a challenge in achieving greater productivity and better quality product especially on the new generation high-speed machines. Advancement in directly compressible materials has come in the form of co-processed spray dried materials. The present work evaluates and characterizes two spray dried co-processed materials, one comprising of microcrystalline cellulose, colloidal silicon dioxide and cross povidone and the other composed of microcrystalline cellulose, colloidal silicon dioxide and sodium starch glycollate. Prototype tablet formulations were developed with these co-processed materials using actives such as diclofenac sodium, iron polymaltose complex and amoxycillin trihydrate. Their performance was compared vis-à-vis conventionally processed tablet formulations as well as with leading marketed brands. This study revealed that the co-processed materials have excellent flow properties, high compressibility, render low disintegration time to tablets and have better binding properties. These materials can be a good substitute for inert granules, which are normally used in tablet manufacturing.

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Author(s): Amelia Avachat VJ Ahire

 
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