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The objective of the present study was to study the physical characterization of Captopril-ethyl cellulose microspheres by thermal analysis such as Differential Scanning Calorimetry (DSC), Differential thermal analysis (DTA) and Thermo gravimetry (TG). Drug polymer interaction can directly affect the dosage form stability, drug encapsulation into polymers and dissolution patterns. In this study thermal analysis has been carried out for the physical mixtures and microspheres of captopril and ethyl cellulose prepared by solvent evaporation method.
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Author(s): Rakesh Gupta CNithya Shanthi Arun K Mahato
DSC, DTG, TG, microspheres, Captopril, ethyl cellulose.