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To dosage form design characterization of drug and polymers is an important aspect. The objective of this work was to characterize Capecitabine, natural polymers like, guar gum, xanthan gum, chitosan and other excipients. As a part of characterization studies of Capecitabine, Differential scanning calorimetry (DSC) was used to investigate thermal effects and nature of drug, supported by X-ray powder diffraction (X-RPD), showed two endothermic peaks and indicated crystalline nature of the drug. Scanning electron microphotographs (SEM) was used to study surface topography. Fourier - transform infrared (FT-IR), solubility study, flowability studies of drug and excipients were carried out as part of characterization. Solubility studies at different pH showed feasibility of drug at any pH. Drug excipient interaction studies carried out which shows there was no chemical interaction between the drug and the polymers. Stability of bulk drug at accelerated conditions was determined, good stability was observed.
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Author(s): Tanaji N Kiran BS
Characterization, DSC, X-RPD, Capecitabine, Polymers, Stability