alexa Abstract | Characterization of Drug and Polymers for Development of Colon Specific Drug Delivery System

Asian Journal of Biomedical and Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

To dosage form design characterization of drug and polymers is an important aspect. The objective of this work was to characterize Capecitabine, natural polymers like, guar gum, xanthan gum, chitosan and other excipients. As a part of characterization studies of Capecitabine, Differential scanning calorimetry (DSC) was used to investigate thermal effects and nature of drug, supported by X-ray powder diffraction (X-RPD), showed two endothermic peaks and indicated crystalline nature of the drug. Scanning electron microphotographs (SEM) was used to study surface topography. Fourier - transform infrared (FT-IR), solubility study, flowability studies of drug and excipients were carried out as part of characterization. Solubility studies at different pH showed feasibility of drug at any pH. Drug excipient interaction studies carried out which shows there was no chemical interaction between the drug and the polymers. Stability of bulk drug at accelerated conditions was determined, good stability was observed.

To read the full article Peer-reviewed Article PDF image

Author(s): Tanaji N Kiran BS

Keywords

Characterization, DSC, X-RPD, Capecitabine, Polymers, Stability

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us