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Original Articles Open Access
The seed oil of the highly promoted food plant Moringa oleifera Lam was extracted by solvent extraction using Soxhlet apparatus. The oil was methylated and analyzed on a Shimadzu GC-MS QP2010 SE.The oil was also screened against local strains of Mycobacterium tuberculosis by tetrazolium dye microbroth dilution assay and was found to be active at 25% (v/v). The result of GC-MS analysis of the methylated oil revealed 15 chemical components. The three major fatty components of the oil were oleic acid (58.88%), palmitic acid (26.16%) and glycerylmonooleate (5.27%). The anti-tubercular activity of the oil was attributed to the oleic acid and palmitic acid content. The oil could be a substitute for other oleic acid rich edible oil as well as a raw material for industrial production of oleic and palmitic acid derivatives and oleochemicals. The findings in this study could be exploited in new anti-tubercular drug research and drug design.
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Author(s): Egharevba H O Oladosu P Izebe K S and Kunle O F
Moringa oleifera, Mycobacterium tuberculosis, seed oil, oleic acid, palmitic acid, glycerylmonooleate