alexa Abstract | Chemistry of Phosphonium Ylides. Part 35. Reaction of Trimethyl Tinazide with Phosphonium Ylides. Synthesis of Antitumor Phosphanylidene Stannanyl Triazole and Triazene Compounds

Journal of Chemical and Pharmaceutical Research
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Abstract

The reaction of 4-azidotrimethylstannane (1) with the nucleophilic active phosphacumulene ylides 2a-c, took place by 1,3-dipolar cycloaddition to give phosphanylidene triazole derivatives 3a-c. Furthermore, the reaction of the azide 1 with hexaphenylcarbodiphosphorane (4) behaves differently and afforded the corresponding phosphanylidene triazene 6 and triphenylphosphane. Treatment of the azide 1 with the stabilized phosphonium ylide, methoxycarbonylmethylenetriphenylphosphorane (8) afforded the triazole (10) along with triphenylphosphine oxide. The antitumor activity of compounds 3b and 3c was evaluated, in vitro against (breast: MCF 7 and liver: HEPG 2) human solid tumor cell lines. They showed values closed to that recorded by the reference drug Doxorubicin.

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Author(s): Soher S Maigali Mansoura A AbdElMaksoud and Fouad M Soliman

Keywords

Tinazide, Phosphoranes, Triazoles, Triazene, Antitumor activity., Phosphanylidene

 
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