alexa Abstract | Chemosensitivity of Hybridoma Cell Lines to Actinomycin D and Bleomycin Sulfate Compared to Non-hybridoma Cell Lines

Electronic Journal of Biology
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)


Cytogenetic effects of two clastogenic antitumor agents, actinomycin D and bleomycin sulfate were assessed in G2 phase of cell cycle in two heterohybridoma cells, and two non-hybrid cell lines. Since heterohybridoma cells carry chromosome constitutions from different species, their responses to various environmental stimuli may vary and depend on their chromosomal origins. Two hybridoma cell lines, HF2x653 and F3B6, and two nonhybridoma cell lines, WIL2 and NS-1, as their parents were treated with bleomycin sulfate and actinomycin D in G2 phase of the cell cycle. Metaphase spreads were prepared and various types of chromatid aberrations were scored. The frequencies of chromatid aberrations of hybrid lines in both treatments were between the frequencies of WIL2 and NS-1. HF2 showed same chromosome aberration frequency with WIL2 and F3B6 with NS-1. The results indicated that chemosensitivity of hybridoma cell lines investigated in this study was nearly similar to their parental cell lines.

To read the full article Peer-reviewed Article PDF image

Author(s): N Jouyan H Mozdarani M A Shokrgozar V Farahat B Saffari


Actinomycin D, Bleomycin Sulfate, Hybrid cell, Chromosome aberration

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version