alexa Abstract | Chromosome aberration and irregular cell cycle in Allium cepa root cells caused by different concentrations of Alprazolam

International Journal of Collaborative Research on Internal Medicine & Public Health
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

Introduction: Allium cepa is a biological material of great importance for mutagenicity tests, due to the simplicity of its use in testing, the fast growth of its roots, and the response of genetic material to the presence of substances with cytotoxic and genotoxic potential.

Method: The Allium test model by using the onion seed (Alium cepa L.) without the use of pesticides or any other chemicals is used in this research. Progressive changes in Allium cepa’s chromosomes caused by treating Allium cepa’s roots in selected drug concentration of 1, 10, 50 and 100 μg/ml of Alprazolam were followed. For statistical analysis chi-square test with the level of significance set at P≤0.05 is used.

Results: Changes in the structure and number of chromosomes in mitosis were found.

Conclusion: Comparing the results obtained for genotoxicity of Alprazolam with those obtained in the experiments that have been performed on other preparations of this group of drugs it can be stated that Alprazolam has similar effects on the cell cycle. Because of potential risk of using Alprazolam another experiment with higher concentration of Alprazolam would give more sufficient information.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Jasmin Musanovic Nerman Ramic Hilada Nefi Amela Dzubur

Keywords

Alprazolam, Allium cepa, root, chromosome, genotoxic

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords